Commercialization of Safer, Affordable Heparin Products to Fuel Global Heparin Market

Deep vein thrombosis/pulmonary embolism (DVT/PE) is causing an astounding number of deaths globally. More so because this medical condition often goes undiagnosed. However, this condition is treatable; with the growing awareness related to DVT and PE, more attention is now being paid to drugs that can keep DVT under check. Heparin is one such anticoagulant that has proven effective in addressing and inhibiting the coagulation cascade. Administered either subcutaneously or intravenously, heparin prevents Factor Xa and antithrombin from causing blood coagulation.

Heparin therapy is recommended for a wide range of conditions, right from people who have suffered a stroke to those with an unstable angina to transient ischemic attack to pulmonary embolism. After warfarin, heparin ranks as the most commonly used anticoagulant, especially in surgical procedures. All of these factors will contribute in creating a US$14.3 bn opportunity in the heparin market globally by 2023. This marks a substantial rise from the 2014 value of the global heparin market, which was US$8.2 bn. These growth projections, published recently by Transparency Market Research, indicate that the global heparin market will log a CAGR of 6.3% between 2015 and 2023.

Regions Creating Favorable Conditions for Growth of Global Heparin Market

North America: The incidence of DVT/PE and cardiac diseases is rising at an alarming rate in North America. Studies in the United States have shown that about 50% of all DVT/PE patients are reported to suffer from further complications arising from the medical conditions and about a third of DVT/PE patients in the U.S. face a high risk of the medical condition recurring.

The U.S. FDA stated in 2014 the country imports a whopping 75% of all crude porcine heparin required for active pharmaceutical ingredient (API) manufacturing. Taking cognizance of this aspect, the U.S. Center for Drug Evaluation and Research (CDER) put forth a proposal asking for bovine sourced heparin to be reintroduced in the country. Heparin sourced from bovines was banned in the U.S. about two decades ago as a precautionary measure against bovine spongiform encephalopathy (BSE) outbreaks. This factor is expected to significantly contribute to the growth of the heparin market in North America.

Europe: Europe is yet another region that contributes heavily to the global demand for heparin. There are several reasons for Europe being one of the leading consumers of heparin. Rapidly growing geriatric populations coupled with a considerably high number of people suffering from coagulation disorders help create factors conducive to the growth of the Europe heparin market. The NHS U.K. estimates that at least one in every 1,000 patients in the United Kingdom suffers from DVT every year. Similar factors are fuelling the heparin market in other European countries such as Germany, France, and Spain.

Asia Pacific: In the near future, Asia Pacific and Rest of the World (RoW) will create ample opportunities for the growth and expansion of the heparin market. The overall enrichment of the healthcare infrastructure and a noticeable rise in the number of surgical procedures conducted in countries such as India and China will stimulate demand for heparin as a coagulant.

However, market analysts also observe that the growth prospects of the global heparin market will be marred to some degree by the reported adverse effects of heparin. Heparin-induced hemorrhage and thrombocytopenia, for instance, are major concerns associated with the administration of unfractionated heparin therapy.

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